A new simple, precise, accurate and cost effective UV spectrophotometric method has been developed for the estimation of Cefpodoxime and Ofloxacin in combined dosage form by simultaneous equation method. This method utilized methanol as common solvent. The wavelength selected for simultaneous equation method for Cefpodoxime shows λmax 235nm and for Ofloxacin shows λmax 298nm. The drugs follow the Beer-Lamberts law in the concentration range of 2-10mcg/ml. The method was validated by following analytical parameters as suggested by the ICH guideline which included accuracy, precision, assay LOD and LOQ. All validation parameters were within acceptable range. The correlation coefficient of Cefpodoxime and Ofloxacin was found to be 0.9995 and 0.999 respectively. Recovery studies for Cefpodoxime 103.56 % and 102.58% for Ofloxacin in case of simultaneous equation method confirming the accuracy of the proposed method. The proposed method is recommended for routine analysis.
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